The relationships of serum levels of leptin, tumor necrosis factor-alpha, free fatty acid and resistin with insulin resistance in type 2 diabetes
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 1
- DOI:
- 10.3321/j.issn:1006-6187.2006.01.003
- Key Word:
- 糖尿病,2型;脂肪细胞因子;胰岛素抵抗;Insulin resistance
Abstract： Objective To explore the relationships of serum levels of leptin,TNF-α,FFA and resistin with IR and between themselves. Methods 48 T2DM patients and 47 non-diabetic controls were selected.Levels of leptin,TNF-α,FFA and resistin were measured.FPG,insulin,blood lipid,blood pressure,BMI and WHR were measured.Results The levels of leptin,TNF-α,FFA and resistin were correlated positively with HOMA-IR(P<0.05-0.01).There were the postive correlations between any two of the levels of leptin,TNF-α,FFA and resistin except for between leptin and resistin.BMI,TG,TNF-α and resistin were the independent risk factors for HOMA-IR in T2DM.(Conclusion)BMI,TG,TNF-α and resistin as independent risk factors for IR may be involved in T2DM development.
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