The effect of captopril on nitric oxide, endothelin and C-reactive protein in patients with type 2 diabetes mellitus

( views:113, downloads:0 )
Author:
BAI Yu-yun()
ZHANG Fa-cheng()
LI Hai-ying()
()
()
()
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
Volume 13, Issue 06, 2005
DOI:
Key Word:

Abstract: Objective To investigate the changes of serum nitric oxide (NO), endothelin(ET)and C-reactive protein(CRP) in patients with type 2 diabetes mellitus and the effect of captopril on the changes. Methods 120 type 2 diabetic subjects were randomly assigned into conventional (CV) treatment group and captopril (CP) group.The captopril group was given captopril in addition to conventional treatment.The serum NO,ET and CRP concentration were measured before and 1,2,3 and 6 months after treatment, which were compared with those in 50 normal control (NC). Results The level of NO was significantly lower (23±6 vs 37±8 μmol/L), while the levels of ET and CRP significantly higher in type 2 diabetic subjects than those in NC group (94±19 vs 57±14 μg/L,and 4.6±2.1 vs 2.3±1.2 mg/L,all P<0.05).In the CP group after 2 months treatment the NO level increased significantly ( from 23±7 to 29±6μmol/L,P<0.05) and the level of ET decreased significantly (from 95±19 to 80±22 μg/L,P<0.05). After 3 months treatment, the level of CRP decreased significantly (from 4.7±1.3 to 3.3±1.1 mg/L,P<0.05). In CV group, the levels of NO, ET and CRP didn’t significantly change in a preiod of 6 months’ following-up. Conclusion Endothelial dysfunction and chronic inflammation within the vascular intima are present in patients with type 2 diabetes mellitus.Captopril improves the endothelial dysfunction and reduces the inflammation in the intima.

  • [1]Kinlay S, Ganz P. Relation between endothelial dysfunction and the acute coronary syndrome: implication for therapy. Am J Cardiol, 2000, 86(suppl):10J-14J.
  • [2]Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med, 1999,340:115-126.
  • [3]Weiss D, Sorescu D, Taylor WR. Angiotensin Ⅱ and atherosclerosis. AM J Cardiol, 2001, 87(suppl) :25C-32C.
  • [4]蔡蓉,高艳虹.C-反应蛋白与人类总病死率、心血管疾病死亡率以及心血管危险因素的关系.国外医学心血管疾病分册,2001,28:312-313.
  • [5]Fichtschlerer S, Rosenberger G, Walter DH, et al. C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation, 2000,102:1000-1006.
  • [6]Willams SB, Cusco JA, Rodoly MA, et al. Impaired nitric oxide mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J Am Coll Cardiol, 1996, 27: 567-674.
  • [7]Willams B. Angiotensin Ⅱ and the pathophysiology of cardiovascular remodeling. Am J Cardiol, 2001, 87(suppl): 10C-17C.
  • [8]Schmidt-ott KM, Kagiyama S, Phillips MI. The multiple actions of angiotensin Ⅱ in atherosclerosis. Regul Pept, 2000, 93:65-77.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn