The relationship between latent autoimmune diabetes in adult(LADA) and HLA-DQ and DR gene

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Author:
LI Qiang()
PAN Hong-yan()
CHEN Li-li()
()
()
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Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
Volume 13, Issue 06, 2005
DOI:
Key Word:

Abstract: Objective The relationship between LADA and HLA-DQ and DR genes was studied. Methods The genotypes of HLA-DR and DQ in 60 healthy controls, 41 patients with type 1 diabetes, 39 patients with LADA were determined by PCR-SSP. Result (1)HLA-DR3,DR4,HLA-DQA1*0301,DQB1*0201 were positively associated with type 1 diabetes; HLA-DR15, HLA-DQB1*0601 were negatively associated with type 1 diabetes.(2)The frequencies of HLA-DR4,HLA-DQ*0301,HLA-DQB1*0201 were positively associated with LADA,and the frequencies of HLA-DQB1*0601 were significantly higher in LADA group than those in type 1 diabetic group. Conclusion Different genetic background may influence the progression of LADA and type 1 diabetes.

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