The relationship between latent autoimmune diabetes in adult(LADA) and HLA-DQ and DR gene
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 6
- DOI:
- 10.3321/j.issn:1006-6187.2005.06.013
- Key Word:
- 糖尿病,1型;成人隐匿性自身免疫性糖尿病;HLA-DQ基因;HLA-DR基因;HLA-DR gene
Abstract： Objective The relationship between LADA and HLA-DQ and DR genes was studied. Methods The genotypes of HLA-DR and DQ in 60 healthy controls, 41 patients with type 1 diabetes, 39 patients with LADA were determined by PCR-SSP. Result (1)HLA-DR3,DR4,HLA-DQA1*0301,DQB1*0201 were positively associated with type 1 diabetes; HLA-DR15, HLA-DQB1*0601 were negatively associated with type 1 diabetes.(2)The frequencies of HLA-DR4,HLA-DQ*0301,HLA-DQB1*0201 were positively associated with LADA,and the frequencies of HLA-DQB1*0601 were significantly higher in LADA group than those in type 1 diabetic group. Conclusion Different genetic background may influence the progression of LADA and type 1 diabetes.
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