Inhibitory effects of arachidonic acid on the expressions of monocyte chemoattractant protein-1 (MCP-1) and intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial cells treated with palmitic acid

( views:111, downloads:0 )
Author:
XIAO Yu-jun()
MU Yi-ming()
ZHAN Xiao-rong()
()
()
()
()
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
Volume 13, Issue 04, 2005
DOI:
Key Word:

Abstract´╝Ü The study on human vascular endothelial cell line (ECV-304 cells) showed that palmitic acid (PA) increased the expression levels of MCP-1 and ICAM-1, while arachidonic acid decreased them induced by PA.

  • [1]Calles-Escandon J and Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocrine Review,2001,22:36-52.
  • [2]Misra A, Kumar S, Kishore Vikram N, et al. The role of lipids in the development of diabetic microvascular complications: implications for therapy. Am J Cardiovasc Drugs,2003,3:325-338.
  • [3]Linton MF, Fazio S. Macrophages, inflammation, and atherosclerosis. Int J Obes Relat Metab Disord,2003,27(suppl 3):s35-40.
  • [4]Gosling J, Slaymaker S, Gu L, et al. MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B. J Clin Invest,1999,103:773-778.
  • [5]Rajavashisth T, Qiao JH, Tripathi S, et al. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice. J Clin Invest,1998,101:2702-2710.
  • [6]Ross R. Atherosclerosis-an inflammatory disease. New Engl J Med,1999,340:115-126.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn