The effect of hyperglycaemia on the islet β-cell responsiveness in type 2 diabetic patients

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Volume 12, Issue 04, 2004
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Abstract: Objective To evaluate the effect of chronic hyper glycaemia on the pancreatic β-cell response in diabetic patients. Me thods We investigated the effect of various blood glucose levels on the β-cell response to stimulation with a standard oral glucose or intravenous gl ucagon in 118 patients with type 2 diabetes. Results The rele ases of C-peptide and insulin were decreased with increased level of fasting blood glucose (P<0.01)after oral glucose stimulation, and were increased with decreased levels of fasting blood glucose after glucagon stimulation wh ile C-peptide and insulin release keeping higher when fasting blood glucose lev el was above 9 mmol/L. The release of insulin showed an inverse association to HOMA-IR (P<0.01)after oral glucose stimulation and it showed a positive association with HOMA-β(P<0.01)after glucagon stimulation. C onclusions The evaluation of function of β-cell secretion is confused by glucose toxicity because severe hyperglycaemia significantly reduces C-pep tide and insulin release after oral glucose stimulation, but this is not the cas e after glucagon stimulation in type 2 diabetic patients.

  • [1]Boden G, Ruiz J, Kim CJ, et al. Effects of prolonged glucose infusion on insulin secretion, clearance, and action in normal subjects. Am J Physiol, 1996,270(2 Pt 1):E251-258.
  • [2]Kawai K, Yokota C, Ohashi S, et al. Evidence that glucagon stimulates insulin secretion through its own receptor in rats. Diabetologia, 1995, 38:274-276.
  • [3]Straub SG, James RF, Dunne MJ, et al. Glucose activates both K(ATP) channel-dependent and K(ATP) channel-independent signaling pathways in human islets. Diabetes, 1998,47:758-763.
  • [4]Gjessing HJ, Reinhold B, Pedersen O. The effect of chronic hyperglycaemia on the islet B-cell responsiveness in newly diagnosed type 2 diabetes. Diabet Med, 1992,9:601-604.
  • [5]Ko GT, Chan JC, Woo J, et al. The reproducibility and usefulness of the oral glucose tolerance test in screening for diabetes and other cardiovascular risk factors. Ann Clin Biochem, 1998,35:62-67.
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