Effects of berberine on glucose and lipid metabolism in animal experiment

( views:146, downloads:0 )
Journal Title:
Volume 12, Issue 03, 2004
Key Word:

Abstract: Objective To investigate the effects of berberine on the insulin sensitivity, the blood glucose and the blood lipid with experimental animals Methods Seven groups of rats were used: routine diet control, routine diet plus berberine treatment, high fat control, high fat plus berberine treatment, diabetes control, diabetes treated by berberine and diabetes treated by metformin The diabetic rats were induced by high fat diet and a very small dose streptozotocin All rats were treated for 5 weeks Islet function was evaluated by glucose tolerance test Insulin sensitivity was detected by the glucose lowering rate (GLR) of insulin tolerance test Results (1) The GLRs of diabetic rats treated by berberine were elevated by 48%, which was better than that of metformin The insulin sensitive indexI of high fat rats treated by berberine was increased by 78% The descent of GLRs of routine diet rats was delayed by berberine too; (2) Fasting blood glucose and loading blood glucose were lowered by berberine significantly; (3) Serum free fatty acids (FFA) of routine diet rats, high fat rats and diabetic rats were decreased by 14%, 24% and 20% respectively regarding the effect of berberine Serum triglyceride of high fat rats treated by berberine was decreased by 57% in the presence of berberine Conclusions Berberine has remarkable insulin sensitizing and serum FFA lowering effects It still has a hypoglycemic effect on high fat rats

  • [1]陈其明,谢明智.黄连及小檗碱降血糖作用的研究.药学学报,1986,21:401-406.
  • [2]宋菊敏,毛良,施建玲,等.黄连素对非胰岛素依赖型糖尿病大鼠的抗氧化作用.中草药,1992,23:590-591.
  • [3]Yin J, Hu R, Chen M, et al. Effects of berberine on glucose metabolism in vitro. Metabolism, 2002,51:1439-1443.
  • [4]江苏新医学院,编.中药大辞典.上海:上海科学技术出版社,1996.2024-2025.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn