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Association of serum C3 and plasma ASP with insulin resistance and dyslipidemia in type 2 diabetic patients

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
3
DOI:
10.3321/j.issn:1006-6187.2004.03.009
Key Word:
酰化刺激蛋白;补体C3;游离脂肪酸;2型糖尿病;胰岛素抵抗;Acylation stimulating protein;Complement C 3; Free fatty acid; Type 2 diabetes mellitus; Insulin resistance

Abstract: Objective The aim of the study is to define the relationship among plasma acylation stimulating protein, complement C 3,obesity, type 2 diabetes and dyslipidemia, as well as the role of ASP and C 3 in insulin resistance in Wuhan population Methods 187 subjects were studied 82 diabetic patients and 105 non diabetic subjects were put into four groups: obese diabetic group (BMI≥25 kg/m 2), diabetic group with normal body weight (BMI<25 kg/m 2),obese group without DM (BMI≥25 kg/m 2) and control group (BMI<25 kg/m 2) Plasma ASP and FFA were determined by ELISA and plasma insulin by electrochemiluminescence immunoassay Plasma glucose, lipid profiles and serum C 3 were also measured using fasting samples LDL C and HOMA IR were calculated Results The concentration of plasma ASP was higher significantly in normal weighted diabetic group [(67±38) nmol/L] and obese group [(60±29) nmol/L] than in control group [(45±21) nmol/L], as well as the concentration of serum C 3 was significantly higher in obese diabetic group [(2 8±1 2) g/L] than in control group [(1 9±0 9) g/L] Also the ratio of ASP/C 3 was significantly higher in OB group [(0 7±0 1)mol/mol] than in NO group [(0 5±0 4)mol/mol] Univariate analysis showed plasma ASP to be positively correlated with BMI, TC, FFA and FPG( r=0 191,P=0 009; r=0 146,P=0 049; r=0 132,P=0 05; r=0 140,P =0 05 respectively);C 3 was positively correlated with FPG, FIN and HOMA IR( r=0 212,P=0 003;r=0 263,P=0 0002;r=0 270,P= 0 0001 respectively) And plasma ASP was not associated with serum C 3 Conclusion ASP and C 3 are independently associated with diabetes and not regulated coordinately Both ASP and C 3 are strongly associated with diabetic status and lipid parameters The lack of correlation between ASP and its precursor C 3 suggests that the conversion of C 3 to ASP is controlled by some factors other than precursor C 3 The increased plasma ASP in both non obese (DN) and obese (DO) diabetics may be suggestive of an ASP resistance

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