Abstract: Objective To explore the effect of multifactorial, targeted intervention of metabolic syndrome (MS) in newly diagnosed type 2 diabetic patients Methods 104 newly diagnosed type 2 diabetic patients without atherosclerosis(AS) were designed to experience the prospective targeted intervention, including the control of blood glucose, blood pressure, blood lipid and body weight, and taking aspirin as well The MS components were examined after 1 year intervention Results The levels of metabolic parameters such as BMI, HbA 1c,TG,sBP and dBP,24 hUAlb, HOMA IR, high sensivity C reactive protein, intimal media thickness of common carotid artery and femoral artery were significantly improved after one year intervention ( P <0 05) The 62 5% (65/104) patients with MS changed to the state without MS MS components in 92 3%(96/104) patients reduced at least one component The targeted percentages(Δ%)of MS components were significantly higher in HbA 1c(60 6%),TG(45 2%),24 hUAlb(33 7%),dBP(33 7%)and sBP(29 9%)than in BMI(14 5%),HDL C(13 5%)and WHR(1 9%)( P <0 05) Conclusions MS severity can be improved in newly diagnosed type 2 diabetic patients with MS after taking multifactorial, intensive intervention The effects of the intervention on MS components varies, central obesity and low HDL C level being tough for control during mutifactorial intervention