Abstract： Objective To evaluate the significance of color doppler ultrasonography (CDU) on the diagnosis of the prevalence, location of superficial macrovascular lesions in type 2 diabetes mellitus. Methods The thickness from intima to media of the anterior or posterior wall was detected on common carotid artery, carotid sinus, common iliac artery, femoral artery and brachial artery through broadband probe in the rated range during the diastolic period. Results 236 patients with type 2 diabetes mellitus were examined by CDU. 85(36%) of patients suffered from one or more angiopathy. There were 143 macrovascular lisions in all. The rates of vascular lesions occured in femoral artery and common iliac artery were significantly higher than that in common carotid artery, carotid sinus (CS) and brachial artery (P<0.01). The appearence of two or more vessel lesions was much higher than that of single vessel lesion (P<0.01). Angiopathy occured frequently in posterior wall and branch of vessel (includeing CS). Conclusions CDU can diagnose atherosclerosis and other angiopathies immediately and noninvasively. Multiple blood vessels measurement can help the diagnosis of type 2 diabetes mellitus and is beneficial to the therapy.