Abstract: Objective To realize the current status of therapies on diabetic patients with ACS. Methods Analysis of the morbidity of diabetes mellitus was done in 1301 patients with ACS who were registered from 12 cardiovascular center in China, and the observation on the clinical status of these patients was carried out. Reperfusion strategies were observed, and the predictor variables of no reperfusion were analyzed. Results (1)Nearly 21.5% patients suffered diabetes mellitus in ACS patients; (2)The morbidity of hypertension and hyperlipidemia were more frequent in diabetic patients than those in non-diabetic patients; (3)Multivariable logistic regression analysis suggested that age>75, stroke and heart failure were predictors of no reperfusion (OR was 2.393, 2.303, 2.828 respectively). (4)The occurrence of in-hospital recurrent angina, congestive heart failure and cardiogenic shock was lower in patients who received PCI therapies than that in patients who received no reperfusion therapy.(5)The mortality in patients who received PCI therapies reduced obviously compared with that in patients who received no reperfusion therapy (0.0 vs 10.6%). Conclusions (1)The morbidity of diabetes mellitus in ACS patients is nearly 21.5%; (2)The occurrence of hypertension and hyperlipidemia is higher in diabetic patients with ACS than that in ACS patients without diabetes; (3)Patients with history of stroke, heart failure and aged more than 75, are the least likely to receive PCI reperfusion therapy. ④PCI therapy can reduce not only in-hospital mortality but also in-hospital adverse cardiac events in diabetic patients with ACS.