Association of 16189 variant (T→C transition) of mitochondrial DNA with the pathogenesis of type 2 diabetes in Chinese population

( views:166, downloads:0 )
Journal Title:
Volume 12, Issue 01, 2004
Key Word:

Abstract: ObjectiveTo investigate the relationship betwe en 16189 variant (T→C transition) of mitochondrial DNA and pathogenesis of type 2 diabetes in Chinese.MethodsPCR and RFLP were used to detect the 16189 variant of mtDNA in 308 unrelated Shanghai Chinese,including 158 indi viduals with normal glucose tolerance and 150 patients with type 2 diabetes.ResultsThe prevalence of 16189 variant in Shanghai Chinese was h igher than that in white people in the United Kingdom(29% vs 9.9%,P=6.85×1 0 -6 ). The diabetic patients with 16189 variant had lower HOMA-IR level co mpared with those without 16189 variant. furthermore, stepwise multiple regressi on analysis showed the 16189 variant was one of the independent factors contribu ting to HOMA-IR.Conclusion16189 variant (T→C transition) of mtDNA is associ ated with insulin resistance,which is important in the development of type 2 dia betes in Chinese population.

  • [1]Graff C,Clayton DA,Larsson NG. Mitochondrial medicine-recent advances.J Inter Med,1999,246:11-23.
  • [2]Poulton J,Brown MS,Cooper A, et al.A common mitochondrial DNA variant is associated with insulin resistance in adult life.Diabetologia,1998,41:54-58.
  • [3]Matthews DR,Hosker JP,Rudenski AS,et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia,1985,28:412-419.
  • [4]纪立农,高蕾莉,韩学尧. 线粒体16189T→C变异与2型糖尿病遗传易感性的相关性研究.中华医学杂志,2001,81:711-714.
  • [5]Lee HK,Song JH,Shin CS,et al. Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract,1998,42:161-167.
  • [6]Park KS,Song JH,Lee KU, et al.Peripheral blood mitochondrial DNA content correlates with lipid oxidation rate during euglycemic clamp in healthy young men. Diabetes Res Clin Pract,1999,46:149-154.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615