Clinical Study of Matrix Metalloproteinase-9 and transforming growth factor-β1 related with diabetic nephropathy
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 5
- DOI:
- 10.3321/j.issn:1006-6187.2003.05.005
- Key Word:
- 基质金属蛋白酶-9;转化生长因子β1;IV型胶原;糖尿病肾病;Diabetic nephropathy
Abstract： Objective To study whether serum matrix metalloproteinase 9, serum transforming growth factor β 1, serum type C IV collagen concentrations are alternatoin in various stages of patients with T2DM. Methods 64 cases T2DM patients were divided into three groups according to urine albumin excretion rate (UAER):normoalbuminuria (NA)group and microalbuminuria (MA) group and overt diabetic nephropathy (ODN)group. Serum MMP 9,TGF β 1 and C IV were detected in all cases. Results Serum MMP 9 in MA and ODN groups were higher than NA and normal control groups ( P <0.01);Serum TGF β 1 in NA,MA and ODN groups were higher than NC group( P <0.01); Serum C IV in ODN group was higher than other three groups( P <0.01)。 Conclusion Higher Serum MMP 9、TGF β 1 plays an important role in the development of diabetic nephropathy in T2DM.
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