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Relationship of aging and obesity with type 2 diabetes

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
2
DOI:
10.3321/j.issn:1006-6187.2003.02.002
Key Word:
糖尿病;肥胖;衰老;Diabetes

Abstract: Objective To explore the relationship of overweight and obesity with type 2 diabetes (DM) and impaired glucose tolerance (IGT) prevalent rates in the middle and old aged Chinese population. Methods All data were from the database of the 9th 5 years national project of medical research on diabetes epidemiology. We correlated the DM and IGT prevalent rates in 25 896 adult individuals aged 40-99 years with overweight or obesity from 22 populations in 12 areas, China, in 1998. Individuals with overweight (BMI≥24), obesity (BMI≥28), abdominal obese [male: waist circumference (WC)≥85 cm; female: WC?80 cm] and waist to hip circumference ratio (WHR≥ 0. 93) were classified according to China criteria. T2 DM and IGT were diagnosed based on WHO criteria respectively. Results (1) Diabetes (DM, male: R2 = 0. 99,female : R2 = 0. 91) and impaired glucose tolerance (IGT, male ; R2 = 0. 96,female: R2 = 0. 96) prevalence correlated positively with aging. (2) Depending on aging, the relationships between DM and overweight (male: J?2 = 0. 23,female: R2 = 0. 88); and obesity (male: K2 = 0. 96,female: R2 = 0. 99) :and WC(male: R2 = 0. 82, female : R2 = 0. 74) ( and between IGT and WC (male: R2 = 0. 98,female: R2 = 0. 98) were markedly positive. The combination of BMI, WC and WHR, as a specific obesity index to classify the target populations with different grades of obesity status, was positively correlated with DM and IGT prevalent rates separately. 3) Following aging, body mass index (BMI) decreased, but WC and WHR increased with age increment. (4) The relationship between obesity and DM/IGT prevalence following aging were showed positively, but we could not show the positive relationship between DM/IGT and WHR and between IGT and BMI. Conclusion The results show that there are markedly positive relationships of overweight and obesity with DM prevalence.

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