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The effects of short-term continuous subcutaneous insulin infusion treatment on beta-cell function in newly diagnosed type 2 diabetic patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 1
- DOI:
- 10.3321/j.issn:1006-6187.2003.01.005
- Key Word:
- 2型糖尿病;胰岛素;治疗学;胰腺β细胞
Abstract： 目的观察短期持续性皮下胰岛素输注(CSII)治疗对伴明显高血糖的初诊2型糖尿病患者的降糖效果和胰岛β细胞功能的影响. 方法对空腹血糖>11.1 mmol/L的36例初诊2型糖尿病患者进行为期2周的CSII强化治疗,分析比较其治疗前后空腹及餐后2h血糖、糖化血红蛋白A1C、静脉葡萄糖耐量(IVGTT)试验时胰岛素分泌第一时相和胰岛素及C肽曲线下面积、空腹血浆胰岛素原、胰岛素原与胰岛素比值和由Homa模型计算的Homa β、Homa IR等.血浆胰岛素、C肽、胰岛素原浓度均用放免法测定. 结果 2周的CSII治疗显示出快速稳定的降血糖效果.其中35例患者的空腹、餐后2 h血糖分别于治疗后(2.7±1.9) d、(8.5±3.5) d达到良好控制,且未见明显低血糖.胰岛β细胞功能在治疗后获得显著改善:静脉注射葡萄糖后10 min内出现了明显增加的胰岛素、C肽分泌相,更有部分患者可以见到典型的胰岛素第一时相分泌尖峰,胰岛素、C肽曲线下面积和由Homa模型计算的Homa β值均较治疗前明显提高,而胰岛素原、胰岛素原与胰岛素比值则较治疗前明显下降.反映胰岛素抵抗的 Homa IR也较治疗前明显降低. 结论对伴明显高血糖的初诊2型糖尿病患者,短期CSII强化治疗具有快速稳定控制血糖和显著改善胰岛β细胞功能的作用.
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