The effect of insulin secretion function on the development of impaired glucose tolerance and diabetes mellitus in obesity

( views:166, downloads:0 )
Author:
()
()
()
()
()
()
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
Volume 10, Issue 03, 2002
DOI:
Key Word:

Abstract: Objective To investigate the effect of insulin secretion function on the development of impaired glucose tolerance (IGT) and diabetes mellitus (DM) in obesity. Methods Plasma glucose and serum insulin were measured by 100 g flour tolerance test and insulin releasing test in 30 cases of non diabetic with normal glucose tolerance (NGT) (BMI>27). They have been followed for 15 years. Insulin secretion index (HOMA IS) and insulin sensitivity index (ISI) was calculated. Results In obese group, the mean fasting serum insulin (FINS) level was significantly higher ( P <0.001) and well positively correlated with HOMA IS( P <0.01). Insulin sensitivity index (ISI) was significant lower ( P <0.01) and negatively associated with Fasting serum glucose (FPG) ( P <0.001). The prevalence of IGT was 63.3% in the obese group, and the prevalence of type 2 DM was 50%. Conclusion Obesity had significant effect on the incidence and development of IGT and DM. Weight control was a key factor in the development of IGT.

  • [1]Haffner SM,Gonzalez C,Miettinen H,et al. A prospective analysis of the HOMA model: the mexico city diabetes study. Diabetes Care,1996,19:1138-1141.
  • [2]李光伟,潘孝仁,Stephen Lillioja,等. 检测人群胰岛素敏感性的一项新指数.中华内科杂志,1993,32:656-660.
  • [3]史轶蘩,主编.协和内分泌和代谢学. 见现代临床医学丛书.第1版.1999.1310.
  • [4]DeFronzo RA,Ferrannini E. Lilly Lecture 1987:the triumvirate:B cell,muscle,liver:a collusion responsible for NIDDM. Diabetes, 1988,37:667-687.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn