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A study of the association between polymorphism of endothelial nitric oxide synthase gene and diabetic nephropathy

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
2
DOI:
10.3321/j.issn:1006-6187.2002.02.005
Key Word:
糖尿病肾病;内皮细胞型NO合酶;基因;多态性;Diabetic nephropathy Endothelial nitric oxide synthase Gene Polymorphism

Abstract: Objective To investigate the association between a 894 G→T mutation at exon 7 of eNOS gene and diabetic nephropathy in type 2 diabetes mellitus of northern chinese Methods A case control study for 228 chinese subjects (including 143 type 2 diabetes mellitus with or without nephropathy and 85 normal control)was performed The number of the 894 G→T mutation alleles were determined by polymerase chain reaction and restriction fragment length polymorphism(PCR RFLP) method combined by DNA sequencing Results The frequency of the T allele and TG genotype at exon 7 were significantly higher in DN+ group than in DN group and control subjects(P<0 05) Multivariate logistic regression analysis showed that the systolic blood pressure, GHbA1c, TC,TG and the 894 G→T mutation at exon 7 of eNOS gene were risk factors for diabetic nephropathy Conclusion The T allele at exon 7 of eNOS gene are related to diabetic nephropathy in northern chinese type 2 diabetes mellitus The T allele may be a risk factor for development and progression of diabetic nephropathy in chinese subjects

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