You Position: Home > Paper

Association of plasminogen activator inhibitor type-1 4G/5G polymorphism and type 2 diabetes with nephropathy

( views:290, downloads:20 )
Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
6
DOI:
10.3321/j.issn:1006-6187.2001.06.004
Key Word:
血浆纤溶酶原激活物抑制物-1;基因多态性;糖尿病肾病;Plasminogen activator inhibitor 1 Gene polymorphism Diabetic nephropathy

Abstract: Objective To investigate the association of the PAI 1 promoter 4G/5G polymorphism and diabetic nephropathy in type 2 diabetes mellitus of North China.Methods The 4G/5G allele polymorphism in the PAI 1 gene promoter region were genetyped by allele specific PCR in 143 type 2 diabetic patients who had diabetes for over 10 years and 85 normal controls.The activity of PAI 1 was assayed by a chromogenic substrate method.Results Patients with type 2 diabetic nephropathy had a higher frequency of PAI 1 4G/4G genotype (39%) and 4G allele (60.5%) than those without nephropathy (33% and 56.5%),though not significantly ( P >0.05).The plasma PAI 1 activity in the diabeties with nephropathy was higher than that in the subjects without nephropathy ( P <0.05).PAI 1 activity was significantly higher in 4G allele homozygous than those in 4G/5G heterozygous and 5G homozygous ( P <0.005).Conclusion Elevated plasma PAI 1 activity is a risk factor for diabetic nephropathy.The presence of the 4G allele of PAI 1 gene was associated with a higher level of PAI 1 activity,and may involved in the generation of diabetic nephropathy.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn