The study on the association of HLA-DQB1 alleles and type 1 diabetes in childhood

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CHINESE JOURNAL OF DIABETES
Issue:
Volume 9, Issue 05, 2001
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Abstract: Objective The association of HLA DQB1 alleles and type 1 diabetes in childhood (onset:0~14 years old) in Harbin was assessed.Methods PCR/SSOP typing method was used to identify HLA DQB1 alleles in the group of type 1 diabetes patients (n=49) and health controls (n=75).Results The frequencies of DQB1*0201,DQB1*0303 and DQB1*0401 were significantly increased in the patients than in control. But the frequencies of DQB1*0301,DQB1*0501 and DQB1*0601 in the patients were significantly decreased than in control.Conclusion The results suggested that DQB1*0201, DQB1*0303 and DQB1*0401 were the important susceptible alleles, DQB1*0301,DQB1*0501 and DQB10601 were important protective alleles. The resistance conferred by DQB1*0602 was not confirmed in Type 1 Diabetes in the children.

  • [1]Davies JL, Kawaguchi Y, Bennett ST, et al. Ageneme-wide search for human type I diabetes susceptibility genes. Nature, 1994,371:130.
  • [2]Nepom GT, Kwok WW. Molecular basis for HLA-DQ association with IDDM. Diabetes, 1998,47:1177.
  • [3]Awata T, Kuzuya T, Matsuda A, et al. Genetic analysis of HLA class Ⅱ alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. Diabetologia, 1992,35:419.
  • [4]Hu CY, Allen M, Chuang LM, et al. Association of insulindependent diabetes mellitus in Taiwan with HLA class Ⅱ DQB1 and DRB1 alleles. Hum Immunol, 1993,38:105.
  • [5]Penny MA, Jenkins D, Mijovic CH, et al. Susceptibility to IDDM in a Chinese population. Role of HLA class Ⅱ alleles. Diabetes, 1992,41:914.
  • [6]Huang HS, Peng JT, She JY, et al. HLA-encoded susceptibility to insulin-dependent diabetes mellitus is determined by DR and DQ genes as well as their linkage disequilibria in a Chinese population.Hum Immunol, 1995,44:210.
  • [7]Baisch JM, Weeks T, Giles R, et al. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus.N Engl J Med, 1990,322:1836.
  • [8]桑艳梅,颜纯,朱逞,等.HLA-DRB1和DQ基因与胰岛素依赖型糖尿病遗传易感性相关性的联合研究.中国糖尿病杂志,1997,1:3.
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