An investigation on the relationship between sulfonylurea receptor 1 gene intron 24-3t/c polymorphism and blood lipids in Chinese population

( views:159, downloads:0 )
Author:
()
()
()
()
()
()
()
()
()
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
Volume 9, Issue 05, 2001
DOI:
Key Word:

Abstract: Obeject To study the association of sulfonylurea receptor (SUR) 1 gene and blood lipids level.Method We investigated the SUR1 gene intron 24 3t/c polymorphism by polymerase chain reaction (PCR) and appropriate restriction enzyme (PCR RFLP) in 132 couples of type 2 diabetic case control and 282 type 2 diabetic pedigrees. The statistical methods were t test, multiple line regression and family based association test (FBAT).Result In the control group, the level of total cholesterol (TC), low density lipoprotein (LDL) and Apo B were higher in the cc genotype than that in the tt and the tc genotype. FBAT showed that sulfonylurea receptor 1 gene intron 24 3t/c polymorphism was significantly associated with TC, ApoB and BMI.Conclusion Sulfonylurea receptor 1 gene intron 24 3t/c polymorphism is associated with blood lipid level in north Chinese population.

  • [1]Inoue H, Ferrer J, Welling CM, et al. Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians. Diabetes, 1996, 45:825.
  • [2]Hani EH, Clement K, Velho G, et al. Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians. Diabetes, 1997,46: 688.
  • [3]Shi H, Moustaid-Moussa N, Wilkison WO, et al. Role of the sulfonylurea receptor in regulating human adipocyte metabolism.FASEB J, 1999, 13:1833.
  • [4]纪立农,韩学尧,王虹,等.磺脲类药物受体基因多态性与非胰岛素依赖型糖尿病的相关性.中华医学杂志,1998,78:774.
  • [5]冯雁,钱荣立,李琼芳,等.磺脲受体基因多态性与2型糖尿病的相关性.北京医科大学学报,2000,5:458.
  • [6]Curtis D, Miller MB, Sham PC. Combining the SDT and the TDT for Multi-Allelic Markers. AJHG, 1999,64:1785.
  • [7]Horvath S and Laird NM. A Discordaant-Sibship Test for Disequilibrium and Linkage: No need for Parental Data. AJHG,1998,63:1886.
  • [8]Lunetta KL. Farone SV, Biederman J, et al. Family Based Tests of Association and Linkage Using Unaffected Sibs, Covariates and Interactions. Under revision for AJHG. 2000.
  • [9]Sakura H, Ammala C, Smith PA, et al. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. FEBS Lett, 1995,377:338.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn