A study for HSPG gene polymorphism in Chinese type 2 diabetic ne phropathy

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Author:
Yang Tao()
CHEN Jiawei()
Shen Jie()
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
Volume 9, Issue 02, 2001
DOI:
Key Word:

Abstract´╝Ü Objective To explore the association between the heparan sulfate proteoglycan gene (HSPG) polymorphism and diabetic nephropathy in Chinese.Methods A case control study of 326 Chinese subjects including 136 type 2 diabetics with or without nephropathy and 190 non-diabetic control was performed.Genotype frequencies of HSPG2 polymorphism were studied by PCR-RFLP analysis with BamHI digestion.Results There was no difference in genotype frequencies or allele frequencies between normal albuminuria and abnormal albuminuria patients.Moreover,there was no association between diabetic patients and non-diabetic control in allele frequencies as well,but obvious difference in genotype frequencies(0.05> P >0.025) was found.Conclusion Our study showed the lack of association between HSPG polymorphism and diabetic nephropathy in Chinese type 2 diabetics.There may be association between genotype frequencies of HSPG polymorphism and diabetes in statistics.

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