You Position: Home > Paper

Influence of plasma lipid level on the accumulation of glomerula rextracellular matrix in OLETF diabetic rats

( views:234, downloads:12 )
Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
2
DOI:
10.3321/j.issn:1006-6187.2001.02.004
Key Word:
肾小球细胞外基质;2型糖尿病;OLETF大鼠血脂非诺贝特;Glomerular extracellular matrix (ECM) OLETF rats Type 2 diabetes mellitus Hyperlipidemia Fenofibrate

Abstract: Objective To investigate the effect of changes in plasma lipid levels on the accumulation of glomerular extracellular matrix in type 2 diabetic rats.Methods Rats were divided into three groups,namely,normal control,diabetes mellitus treated with Fenofibrate,which was gastrically administrated in the dose of 20mg·kg -1 ·d -1 for 22 weeks.A quantitative analysis of the components of glomerular extracellular matrix (ECM) were performed with immunoperoxide (ABC) method and the computer imagine analysis system.Results The result showed that diabetic rats had significantly higher plasma lipid levels and accumulation of ECM including collagen Ⅳ,laminine and fibronectin than the normal control ( P <0.01).22 weeks after the treatment with Fenofibrate,accumulation of ECM in diabetes treamtnent group was less marked as compared with the diabetes without treatment group ( P <0.05).Conclusion It is suggested that hyperlipidemia play a role in the pathogenesis of diabetic nephropathy.Lipid-lowering therapy may retard the progression of glomerulosclerosis in diabetes mellitus.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn