Association between angiotensin Ⅱ type 1 receptor gene polymorphism and type 2 diabetic retinopathy

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Zhang Li()
Wang Dequan()
Ma Yuyan()
Journal Title:
Volume 9, Issue 01, 2001
Key Word:

Abstract: Objective To explore the association between angiotensin Ⅱ type 1 receptor (AT1R) gene polymorphism and type 2 diabetic retinopathy (DR).Methods 120 cases of type 2 diabetes mellitus (DM) and 40 controls were genotyped for AT1RA 1166C gene polymorphism by using PCR/Dde Ⅰ restriction enzyme digestion.52 cases of 120 cases with DM were complicated with retinopathy DR(+),68 with no retinopathy DR(-).Results The distributions of AT1R gene polymorphism were not different among controls and diabetics.Frequencies of variant gene and genotype of DR(+) were higher than those of DR (-) group and controls.Frequency of C allele in proliferative DR group was higher than that of simple DR group.Logistic regression showed that the duration,fructosamine and systolic blood pressure were risk factors of DR.Conclusion AT1R gene polymorphism is associated with DR,but not DM.AT1R variant allele may contribute to DR.

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