The relationship between human plasma leptin levels and obesity, plasma glucose as well as insulin concentrations

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Author:
Ma Hong()
Gao Yan()
Yang Jianmei()
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Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
Volume 9, Issue 01, 2001
DOI:
Key Word:

Abstract: Objective To investigate the relationship between plasma leptin levels and obesity,plasma glucose as well as insulin concentrations.Methods Fasting plasma leptin concentrations were measured with IRMA in 171 cases (including 84 type 2 DM,36 IGT,51 NGT;90 men,81 women),and oral glucose tolerance test was done in every case to measure plasma glucose and insulin concentrations.Height,body weight were measured to calculate body mass index (BMI).Results Fasting plasma leptin levels are correlated with BMI( r=0.6772,P <0.01 in male and r=0.7191,P <0.01 in female),and leptin levels were 2~3 times higher in female than in male ( P <0.001).The stepwise multiple regression analysis shows that leptin variations were positively correlated with insulin curve areas.Conclusion Fasting plasma leptin levels are higher in obese subjects than that in non obese ones.The correlation between hyperleptinemia and hyperinsulinemia suggests a possible role for leptin in type 2 diabetes pathogenesis.

  • 1 Zhang Y,Proeca R,Maffei M,et al.Positional cloning of the mouse obese gene and its human homologue.Nature,1994,372:425.
  • 2 Tartaglia LA,Dembski M,Weng X,et al.Indentification and expression clone of a leptin receptor OB-R.Cell,1995,83:1263.
  • 3 Stejskal D,Ruzicka V,Hrubiskova L,et al.Leptin in persons with simple obesity.Vnitr-Lek,1997,43:555.
  • 4 顾卫琼,陈名道,唐金凤,等.中国人血清瘦素水平与肥胖度的关系.中华内分泌代谢杂志,1999,15:15.
  • 5 Lonnqvist F,Arner P,Nordfors L,et al.Over expression of the obese (ob) gene in adipose tissue of human obese subjects.Nature Med,1995,374:950.
  • 6 Caro JF,Kolaczynski JW,Nyce MR,et al.Decreased cerebrospinal-fluid/serum leptin ration in obesity a possible mechanism for leptin resistance.Lancet,1996,348:159.
  • 7 D'Adamo M,Buongiorno A,Maroccia E,et al.Increased ob gene expression leads to elevated plasma leptin concentrations in patients with chronic primary hyperinsulinemia.Diabetes,1998,47:1625.
  • 8 Campfield L,Smith F,Gulsez Y,et al.Mouse OB protein:evidence for a peripheral signal linking adiposity and central neural networks.Science,1995,269:546.
  • 9 Emilsson V,Liu YL,Cawthorne MA,et al.Expression of the functional leptin receptor mRNA in panceratic islets and direct inhibitory action of leptin on insulin secretion.Diabetes,1997,46:313.
  • 10 Fehmann HC,Berghofer P,Brandhorst D,et al.Leptin inhibition of insulin secretion from isolated human islets.Acta Diabetol,1997,34:249.
  • 11 Fehmann HC,Peiser C,Bode HP,et al.Leptin:a potent inhibitor of insulin secretion.Peptides,1997,18:1267.
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