The intimal-medial wall thickness of common carotid artery in type 2 DM

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Lu Wenkai()
Miao Xiaoping()
Han Dongshen()
Journal Title:
Volume 8, Issue 05, 2000
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Abstract: Objective In order to ascertain the change of IMT in patients with type 2 DM and the relationship between IMT and various risk factors.Methods Using B-mode ultrasonography to measure the IMT in 123 diabetics and 102 healthy controls and to compare the clinical data between two DM groupes.Results ① The IMT of both diabetics and controls increased with the age.The IMT of every age group was obviously thicker in diabetics than in controls ( P <0 05~ P <0.01).The IMT of diabetics at the age of 30~ and 40~ was the same as that of 50~ and 60~.②The IMT of controls was 0.61±0.07mm,98% of them was <0.8mm.The IMT of diabetics was 0.85±0.41mm,56% of them was ≥0.8mm.③SBP、DBP、the duration of hypertension,FIns,24h UALB,the percentage of CHD and CVD were apparently higher;ISI was obviously lower in group of IMT≥0.8mm than in group of IMT<0.8mm( P <0 05~ P <0.01).There was no significant difference in the duration of DM,the FBG,2hBG、HbA1c,2hIns,TC and TG between two groups.Conclusion The increase of IMT in type 2 DM develops early and rapidly.The increase of UALB is the marker of the thickened IMT.The chance of CHD and CVD in patients with IMT≥0.8mm is increased.It can be seen that hypertention,hyperinsulinimia and insulin resistance accelarate the AS since carly phase.

  • [1]UKPDS group.UK prospective diabetes study 17.A nine-year update of a randomized,controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus.Ann Intern Med,1996,124:134.
  • [2]Commentary.Some answers,more controversy from UKPDS.The Lancet,1998,352:832.
  • [3]Stuout RW.Hyperinsulineimia and atherosclerosis.Diabetes,1996,45:S45.
  • [4]UKPDS group.Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).The Lancet,1998,352:837.
  • [5]Grant PJ,Kruithof EKO,Felley CP,et al.Short-term infusions of insulin,triacylglycrol and glucose do not cause acute increases in plasminogen activaror inhibitor-1 concentrations in man.Clin Sci,1990,79:513.
  • [6]Schneider DJ,Nordt TK,Sobel B.Stimulation by proinsulin of expression of plasminogen activator inhibitor type-1 in endothelial cells.Diabetes,1992,41:890.
  • [7]UKPDS Group.Tight blood pressure control and risk of macrovascular and mictovaskular complication in type 2 diabetes,UKPDS 38.BMJ,1998,317:703.
  • [8]Editorials.Combined high blood pressure and glucose in type 2 diabetes:double jeopardy.BMJ,1998,317:693.
  • [9]施曼珠,张俊清,钱荣立,等.NIDDM患者微量白蛋白尿与冠心病的关系.中国糖尿病杂志,1996,4:131.
  • [10]Schaper NC.Early atherogenesis in diabetes mellitus.Diabetic Medicine,1996,13:S23.
  • [11]Hegele RA.The pathogenesis of atherosclerosis.Clin Chimi Acta,1996,246:21.
  • [12]Defronzo RA,Ferranini E.Insulin resistance,a multifaceted syndrome responsible for NIDDM,obesity,hypertension,dyslipidemia,and atherosclerotic cardiovascular disease.Diabetes Care,1991,14:173.
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