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Apo∈2 allele and hyperlipoproteinemia in Chinese type 2 diabetic patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 5
- DOI:
- 10.3321/j.issn:1006-6187.2000.05.001
- Key Word:
- 载脂蛋白E基因;高脂血症
Abstract： 目的研究2型糖尿病(DM)患者载脂蛋白(Apo)∈2等位基因与高脂蛋白血症(HLP)的关系.方法选择携∈2的2型DM和非DM患者各24例及∈3/3 2型DM患者50例.采用PCR/ASO探针杂交技术检测ApoE基因.结果①∈2 2型DM组HLP发生率为62.5%.显著高于∈2非DM组(33.3%)及∈3/3 2型DM组(36%)(P＜0.05).②∈2 2型DM组HLP包括Ⅱb型(n=2)、Ⅲ型(n=7)、Ⅳ型(n=6).而∈2非DM组包括Ⅲ型(n=1)、Ⅳ型(n=7).③与∈2非DM组相比.∈2 2型DM组及∈3/3 2型DM组总胆固醇、甘油三酯、低密度脂蛋白胆固醇显著增高.∈3/3 2型DM组脂蛋白(a)明显高于其它两组.④与∈2 2型DM正常血脂组相比.∈2 2型DM高脂血症组糖化血红蛋白、空腹血糖水平显著增高(P＜0.05).结论携∈2的2型DM患者.尤其是代谢控制不良者易并发HLP.Apo∈2等位基因可能是2型DM与HLP之间的一个联系因素.
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