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Immunohistochemical study on ICA subsets and its relation to the islet cellular types

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
4
DOI:
10.3321/j.issn:1006-6187.2000.04.006
Key Word:
糖尿病;ICA亚型;弥漫型ICA;边缘型ICA;免疫组化双标技术;Diabetes mellitus ICA subset Diffuse pattern Peripheral pattern Immunoenzymatic double labe ling techniques

Abstract: Objective To explore the changes of the two cellular types,the diffuse pattern and the peripheral pattern,in morphological distribution and their clinical significance.Methods 20 cases from the above each pattern were chosen and identified by double labeling immunohistochemical techniques.Results Both α cells and β cells in pancreatic islet were stained in the diffuse pattern,but only α cells in the peripheral pattern.Conclusion The results from our experiment indicated that the diffuse patterns were more frequently observed in the patients with type I diabetes mellitus and existed in those patients who were more younger at onset and the course of disease developed more rapidly in comparison with the peripheral pattern.The diffuse patterns were more frequent in type I DM,and in type Ⅱ DM the frequence of the peripheral patterns was more higher than that of the diffuse pattern.

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