Abstract： Objective The aim of this study was to observe the clinical effect of intravenous thrombolysis therapy on diabetic patients with acute myocardial infarction. Methods In the coronary care unit (CCU) at our hospital, 182 of the patients with acute myocardial infarction were divided into two groups with (DM AMI) and without diabetes (NDM AMI). All patients were treated with intravenous thrombolysis therapy. Results ①Hospital mortality in DM AMI groups was 15 15%, and 6 03% in NDM AMI(χ 2=4 17,P<0 05).The reperfusion rate of infarct related artery (IRA) was 45 45% in DM AMI groups, and 62 93% in NDM AMI groups (χ 2=5 23,P<0 05).②BS、CR、BUN、TC and TG in DM AMI groups were significantly higher than in NDM AMI groups (P<0 001、P<0 05).③Complications of AMI were significantly higher in DM AMI groups than in NDM AMI, with left ventricular failure significantly higher (36 36% vs 12 97%,χ 2=13 72,P<0 001) and cardial shock significantly higher (16 67% vs 6 03%,χ 2=5 33,P<0 05).Conclusion This study showed that intravenous thrombolysis therapy exerted a beneficial effect on the early term prognosis of AMI patients without diabetes. But for the patients with diabetes intravenous thrombolysis therapy did not show a beneficial effect.