Preliminary study Of association between metabOlism Of free radical and sulfonylurea receptOr
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 1
- DOI:
- 10.3321/j.issn:1006-6187.2000.01.006
- Key Word:
- 糖尿病;超氧化物歧化酶;磺脲类药物受体;Diabetes mellitus Superoxide dismutase (SOD) Sulfonylurea receptor (SUR)
Abstract： Objective Probing into the expression of scavenger SOD and SUR’s mRNA in pancreatic tissue of diabetic rats induced by streptozocin to understand relationships between SOD and SUR.Methods We quantified the blood sugar, lipoprotein and the gene expression of SOD and SUR by RT PCR in beta cells of pancreatic tissue at 0, 4, 12, 24 weeks separately.Results Compared with control group, the levels of blood sugar and lipoprotein increased slowly; the levels of expression of SOD and SUR mRNA were lower in beta cells of pancreatic tissue. The relationship between SOD and SUR mRNA was close.Conclusion The results indicated that there was a low expression of SOD and SUR gene in beta cells of pancreatic induced by streptozocin, which become distinct especially during the longer periods of hyperglucose. The changes of SOD mRNA expression in pancreatic tissue may be one of reasons resulting in lowing SUR mRNA levels.
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