Abstract: Objective To evaluate the effect of MP-1 microperimeter in detecting the early retinal abnormalities in diabetic patients and to provide evidences and ways for the prevention and cure of diabetic retinopathy.Methods Twenty-seven diabetic patients without retinopathy (total 51 eyes)and 26 normal control subjects (total 50 eyes) were evaluated.MP-1 microperimeter was used to quantify the retinal sensitivity and the fixation.Results The difference of fixation between diabetic patients without retinopathy and normal control subjects was not significant (P >0.05).The retinal sensitivity in diabetic patients without retinopathy declined significant (P <0.05). Conclusions The early changes of retinal function in diabetic eyes without retinopathy can be detected and quantitatively by the MP-1 microperimeter even before the appearance of diabetic retinopathy,and MP-1 microperimeter is a sensitive method which can provide evidences and ways for the prevention and cure of diabetic retinopathy.