Effect of statins use on the prevention of venous thromboembolism: a meta-analysis
- Author:
- No author available
- Journal Title:
- Journal of Medical Colleges of PLA
- Issue:
- 5
- DOI:
- No doi available
- Key Word:
- Statins;Venous thromboembolism;Meta analysis
Abstract： Objective:To estimate the effect of statins use on the prevention of venous thromboembolism (VTE).Methods:We systematically searched MEDLINE (1980-June 2012),EMBASE (1980-June 2012),Google Scholar,Cochrane Library,and ISI Web of Science,manually reviewed references,and contacted experts.Case-control studies and cohort studies that compared any dose of statin with no statin or placebo are included.Data extraction and study quality evaluation were independently conducted in duplicate.Results:12 studies including four cohort studies and eight case-control studies were identified and eligible for meta-analysis.Upon meta-analysis,statin use was associated with a statistically significant reduction in the odds of developing VTE (OR 0.91,95％ CI 0.86-0.96).Conclusion:This meta-analysis of current and available literature suggests that statins can reduce patient's risk of developing VTE.Due to the limitations of observational Study,this conclusion should be considered with caution,and additionally,specifical well-designed trials are needed.
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