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A two-hit model of autoimmunity: lymphopenia and unresponsiveness to TGF-β signaling
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- Author:
- No author available
- Journal Title:
- Cellular & Molecular Immunology
- Issue:
- 5
- DOI:
- 10.1038/cmi.2012.25
- Key Word:
- No keyword available
Abstract： The immune system can robustly respond to pathogens,while it is capable of maintaining tolerance to self and innocuous antigens,so that the body is not jeopardized by autoimmune reactivity.Under certain circumstances,nonetheless,control of homeostasis of the immune system is suspended,and the body subsequently fails to recognize its own constituent parts as self,which contributes to homeostatic peripheral expansion and autoimmune diseases.
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