Objective To discuss psychological intervention in the course of 13iI therapy for hyperthyroidism value. Methods Select the required 131I treatment of 75 patients with hyperthyroidism were divided into two groups:Psychological intervention group of 45 patients, application of 131I treatment with psychological intervention and nursing; Control group of 30 patients, simple application of 131I treatment. Results Intervention group significantly reduced the recurrence rate of hyperthyroidism, patient treatment satisfaction, symptom improvement and quality of life than the control group was statistically significant (P＜ 0.05). Conclusion Throughout the course of 131I treatment on hyperthyroid patients and their families on psychological interventions is more in line with the development of modern medicine. Have important clinical significance.