Objective To observe the effect of DD and ET-1 in patients with acute exacerbation of chronic pulmonary heartdisease used anticoagulant Therapy. Methods 60 patients in acute exacerbation of chronic pulmonary heartdisease who were randomly divided into treated group and control group. The control group use routine treatment, and treated group were therapied with LMWHC addedly, which based on the routed treatways. Their changes, including hospitalization days, ET-1, and DD were observed. Results Treated group' s hospital stays were shorter than control group. DD、 ET-1 were both decreased (P＜ 0. 05) in treated group have statistical significance. Conclusion Added the anticoagulant in treating chronic pulmonary heartdisease would improve the hypercoagulability and shorten hospitalization days.