Objective To study the effect of valsartan and amlodipine on plasma Apelin-12 in patients with essential hypertension. Methods The 110 mild and moderate hypertension patients were divided randomly into 2 groups, 58 patients were treated in valsartan, 52 patients were treated in amlodipine. 50 healthy people physical examinded were control group. All the cases were detected Apelin-12. After 16 weeks' anti-hypertensine lowering with valsartan and amlodipine for EH group, the above item was detected again. Results The plasma Apelin-12 level after treatment of valsartan and amlodipine was significantly higher than that of treatment before. The plasma Apelin-12 level after treatment of valsartan was significantly higher than that of treatment of amlodipine. Conclusion Valsartan increase plasma Apelin-12 more than amlodipine.