Comparative study to effect of valsartan and amlodipine on plasma Apelin-12 in patients with essential hypertension

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Author:
WANG Shi-xun(Department of Cardiology, Weifang People's Hospital. Weifang 261041, China)
WANG Juan-ling(Department of Cardiology, Weifang People's Hospital. Weifang 261041, China)
LIU Tong-xiang(Department of Cardiology, Weifang People's Hospital. Weifang 261041, China)
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
Volume 04, Issue 12, 2010
DOI:
10.3760/cma.j.issn 1673-8799.2010.12.40
Key Word:
Hypertension;Apelin-12;valsartan;Amlodipine

Abstract: Objective To study the effect of valsartan and amlodipine on plasma Apelin-12 in patients with essential hypertension. Methods The 110 mild and moderate hypertension patients were divided randomly into 2 groups, 58 patients were treated in valsartan, 52 patients were treated in amlodipine. 50 healthy people physical examinded were control group. All the cases were detected Apelin-12. After 16 weeks' anti-hypertensine lowering with valsartan and amlodipine for EH group, the above item was detected again. Results The plasma Apelin-12 level after treatment of valsartan and amlodipine was significantly higher than that of treatment before. The plasma Apelin-12 level after treatment of valsartan was significantly higher than that of treatment of amlodipine. Conclusion Valsartan increase plasma Apelin-12 more than amlodipine.

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