Objective To observe clinical effect of Shengmai injection on dialysis-related hypotension.Methods Seventy patients with dialysis-related hypotension were divided into two groups:experimental group (35 cases)and control group (35 cases). Patients in experimental group was treated with Shengmai injection,while patients in control group were given with conventional treatments. Effective rate and hemodynamics changes were measured in both groups. Results The effective rate in experimental group was significantly higher than control group (P＜ 0.05), while frequency of treatment was lower than control group (P＜ 0. 05). There were no significant difference between experimental group and control group in systolic pressure, diastolic pressure and heart rate (P ＞ 0.05). Conclusion Shengmai injection is effective and safe in dialysis-related hypotension.