Idiopathic pulmonary hemosiderosis: report of one case and literature review

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Author:
LI Chun-hua(The Third People's Hospital of Huizhou City, Guangdong 516001, China)
HUANG Hai-zhong(The Third People's Hospital of Huizhou City, Guangdong 516001, China)
ZOU Qing-mei(The Third People's Hospital of Huizhou City, Guangdong 516001, China)
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
Volume 04, Issue 12, 2010
DOI:
10.3760/cma.j.issn 1673-8799.2010.12.28
Key Word:
Idiopathic pulmonary hemosiderosis;Children;Literature review

Abstract: Objective To summarize the clinical manifestation, laboratory examination, radiological and pathological characteristics of idiopathic pulmonary hemosiderosis in children and discusses the diagnosis,treatment and prognosis. Methods The patient for laboratory, imaging, deep sucking phlegm parallel histopathological examination confirmed, corticosteroid and followed-up, discusse the patient and combined domestic and foreign literature review reports. Results Clinical manifestations of main were recurrent haemoptysis,cough, anemia, partial bosom frowsty, flustered, feeble, no obvious signs in lungs. Radiculopathy lung diffuse ground-glass appearance was changed, relevant immunological tests (e. g, antinuclear antibodies, neutrophils patina antibodies) were negative, blood analysis was a hypochromic microcytic anemia, elevated bilirubin, serum iron reduces, deep sputum containing blood can be found macrophages. Conclusion Children idiopathic pulmonary hemosiderin clinical manifestations of diversity, with iron deficiency anemia, bronchopneumonia, tuberculosis, it is easy to be misdiagnosed, distinguish repeatedly, the diagnosis of gastric juice and bronchoaleolar laage biopsy can improve the rate of disease, should strengthen the cognition, early diagnosis and intervention. Long-range cocorticoid therapy can make an illness in a stable state. The poor prognosis.

  • [1]Nuesslein TG,Rieger CH.Pulmonary haemosiderosis in infants and children.Pardiatr Respir Rev,2006,7:45-48.
  • [2]葛伟,孙若鹏.特发性肺含铁血黄素沉着症研究进展.临床儿科杂志,2007,3(21):232-235.
  • [3]Shibata M,Sakurai Y,Yaamada K,et al.Recurrence of idiopathic pulmonary hemosiderosis associated with rising plasma IgE levels and antibody titers to specific inhalants during a 10-year follow-up Pediatr Allergy Immunol,2005,18 (3):161-166.
  • [4]胡亚美,江载芳.实用儿科学(上册).人民卫生出版社,2002,1242-1245.
  • [5]袁新宇,陈慧中,郭红伟.儿童肺部间质性病变影像学检查.临床儿科杂志,2003,(9):525-527.
  • [6]Yao TC,Hung IJ,Wong KS,et al.Idiopathic pulmonary haemosiderosis:an oriental experience.Paediatr Child Health,2003,39:27-30.
  • [7]佘桂源.特发性肺含铁血黄素沉着症.//李文益,陈述牧.儿科学新理论和技术.人民卫生出版社,2002:174-177.
  • [8]张本山,郑敏翠,杨海霞.儿童特发性肺含铁血黄素沉着症误诊12例分析.中国误诊学杂志,2003,3(10):1559.
  • [9]牟向东,宿利.成人特发性肺含铁血黄素沉着症二例报道及文献回顾.北京大学学报:医学版,2008,45(6):595.
  • [10]Willms H,Gutjahr K,Juergens UR,et al.Diagnostics and therapy of idiopathic ppulmonary hemosidenosis.Medklin (Munich),2007,102:445-450.
  • [11]麦贤弟,谢缓缓.糖皮质激素吸入治疗特发性肺含铁血黄素沉着症1例及随访报告.中国当代儿科杂志,2003,5(6):543-544.
  • [12]Wroblewski BM,Stefanoric CR,McDonough VM,et al.The challenges of idiopathic pulmonary hemosidersis and lung transplantation.Crit Care Nuts,1997,17:39-44.
  • [13]Calabrese F,Giacometti C,Rea F,et al.Recurrence of idiopathic pulmonary hemosiderosis in a young adult patient after bilatreal Single-lung transplantation.Transplantation,2002,74:1643-1645.
  • [14]Saeed MM,Woo Ms,Maclaughlin EF,et al.Prognosis in pediatric idiopathic pulmonary hemosiderosis.Chest,1999,16 (3):721-725.
  • [15]Le Clainche L,Le Bourgeois M,Fauroux B,et al3Longterm outcome of idiopathic pulmonary hemosiderosis inchildren.Medicine (Baltimore),2000,79 (5):318 -326.
  • [16]Blanco A,Solis P,Gomez S,et al3Antineutrophil cytoplassmic antibodyies(ANCA) in idiopathic pulmonary hemosiderosis.Pediatr Allergy Immunol,1994,5 (4):235-239.
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