Ganoderma lucidum spre powder on type 2 diabetes rat testis expression IL-1β, TNF-α influence

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Author:
ZHONG Li-li(Harbin City, Heilongjiang Province First Affiliated Hospital of the University of Chinese Medicine, Harbin 150040, China)
ZHANG Wei-jia()
YIN Li-ying(Harbin City, Heilongjiang Province First Affiliated Hospital of the University of Chinese Medicine, Harbin 150040, China)
()
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
Volume 04, Issue 12, 2010
DOI:
10.3760/cma.j.issn 1673-8799.2010.12.27
Key Word:
Type 2 diabetes;Testis;Interleukin(IL-1β);Tumor necrosis factor-alpha(TNF-α);Ganoderma lucidum spore powder

Abstract: Objective To observe ganoderma lucidum spore powder perishes weakly on type 2 diabetes big mouse testis cell IL-1 β、TNF-α expression influence. Methods 50 Wistar big mouse randomly were divided into 3 groups control group, diabetes group, ganoderma lucidum group. Radioimmunoassay examines testis cell factor IL-1β、TNF-α levels. Results Diabetes group and the normal control group, IL-1β and TNF-α were significantly higher(P< 0. 05). The ganoderma lucidum group and diabetes group, IL-1β、TNF-α levels significantly lower than diabetes group (P< 0.05). Conclusion The ganoderma lucidum spore can effectively reduce the IL-1 β, TNF-α levels in diabetes rats toxic damage to the reproductive system, probably in diabetes rats reproductive system of apoptosis significantly inhibition of testicular cells so protective effect from one of the mechanisms. Ganoderma lucidum spore as a complementary treatment of diabetes treatment in clinical applications,has broad prospects.

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