Curative effects of nerve growth factor on neonates with moderate and sever hypoxic-ischemic encephalopathy

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Author:
CUI Jian-po(Kaifeng Childrens Hospital, Kaifeng 475000, China)
HAO Yan-feng()
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
Volume 04, Issue 12, 2010
DOI:
10.3760/cma.j.issn 1673-8799.2010.12.23
Key Word:
Hypoxic-ischemic;Brain;Nerve growth factor;Infant;Newborn

Abstract: Objective To observe the curative efects of never growth factor (NGF)on neonates with moderate and severe hypoxic-ischemic encephalopathy (HIE). Methods Eighty-six neonates with HIE were randomly divided into NGF treatment group and control group. The control group (42 cases)were received routine treatment (including cerebrolysin and citicoline) ;the treatment group (44 cages)were given NGF on the basis of routine treatment as early as possible (within 6 hours after birth). Brain CT, neonatal behavioral neuro-logical assessment(NBNA) and children' s development center of China(CDCC) at 3 and 6 months after birth were proformed in both groups. Results Brain CT, NBNA and CDCC markers in treatment group were better than those in control group (P< 0. 05). There were great diferences between two groups (P< 0. 01). Conclusion Using NGF on the basis of the routine treatment as early as possible after resuscitation can reduce markely the severity of asphyxia induced brain damage in neonates. It is very effective using NGF in treating HIE in neonates.

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