Study of the effect of hyperbaric oxygenation on activities of serum SOD and CRP and its clinical significance in patients with cerebral infarction

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Author:
NIE Yan-ling(Department of Hyperbaric Oxygenation, The First People's Hospital of Shangqiu, Henan 476100, China)
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
Volume 04, Issue 12, 2010
DOI:
10.3760/cma.j.issn 1673-8799.2010.12.22
Key Word:
Hyperbaric oxygenation (HBO);Cerebral infarction;Superoxide dismutase (SOD);C -reactive protein(CRP)

Abstract: Objective To study the effect of hyperbaric oxygenation(HBO) therapy on the activities of serum SOD and CRP of patients with cerebral infarction and its clinical significance. Methods 78 patients with cerebral infarction were randomly divided into hyperbaric oxygen group (HBO Group, 40 cases)and clinical group (38 cases). The clinical group was treated with clinical conventional treatment only. HBO group was treated with HBO combined with clinical conventional treatment. 21 healthy volunteers were assigned to control group. Before and after treatment, the activities of serum SOD and CRP level were measured, and the curative effect were evaluated. Results The pretreatment serum SOD and CRP of the HBO group and clinical group were significantly different from the control group (P< 0. 01). Compared with the pretreatment and posttreatment serum level of the HBO group, SOD raised, CRP lowered, the difference was significant(P< 0. 01).Compared with clinical group, SOD raised, CRP lowered and the total cure rate of the HBO group were more significant different(P <0.01). Conclusion HBO therapy raised the activities of SOD and lower the level of CRP in serum of the patients with cerebral infarction, and improved the free radicals scavenging ability in the body. Therefore, HBO therapy has a good effect for cerebral infarction. The experiment suggests that the activities of SOD and CRP level in serum can be used to judge the curative effect and prognosis of HBO therapy for cerebral infarction.

  • [1]Jenkins PO,Turner MR,Jenkins PF.What is the place of thrombolysis in acute stroke? A review of the literature and acurrent perspective.Clin Med,2008,8(3):253-238.
  • [2]Al-Waili NS,Butler GJ,Beale J,et al.Hyperbaric oxygen in the treatment of patients with cerebral stroke,brain trauma,and neurologic disease.Adv Ther,2005,22(6):659-678.
  • [3]全国第四次脑血管病学术会议(1995).脑卒中患者临床神经能缺损程度评分标准.中华神经科杂志,1996,29(6):381.
  • [4]Eikelboom JW,Hankey GJ,Baker RI,et al.C-reactive protein in ischemic stroke and its etiologic subtypes.J Stroke Cerebrovasc Dis,2003,12(2):74-81.
  • [5]李卫,邢成名.C-反应蛋白与动脉粥样硬化性心脑血管病.国外医学脑血管疾病分册,2004,12(8):620-623.
  • [6]Archararit N,Chuncharunee S,Pornvoranunt A,et al.Serum Creactive protein level in postsplenectomized thalassemic patients.J Med Assoc Thai,2000,83 (Suppll):S63-S69.
  • [7]Sj..owall C,Wettero J,Bengtsson T,et al.Solid-phase classical complement activation by C-reactive protein (CRP)is inhibited by fluid-phase CRP-C1 q interaction.Biochem Biophys Res Commun,2007,352(1):251-258.
  • [8]Yang SX,DiazPadilla N,Zhu Q,et al.Estrogen replacement raises rat CRP without evidence of complement activation.Endocr Res,2005,31 (2):121-132.
  • [9]Al-Waili NS,Butler GJ,BealeJ,et al.Hyperbaric oxygen in the treatment of patients with cerebral stroke,brain trauma,and neurologic disease.Adv Ther,2005,22(6):659-678.
  • [10]杨思军,谷德祥,曹中拄,等.高压氧对急性脑梗死患者血中ACTH及SOD的影响.中华航海医学杂志,1997,4(4):240-241.
  • [11]Wadak,Miyazawa T,Nomura N.Mn-SOD and Bcl-2 expression after repeated hyperbaric oxygenation.Acta Neurochir,2000,76 (Suppl):S285-290.
  • [12]朱祥祺,倪大智,李慈,等.高压氧对减压病大鼠肺组织自由基的影响.中华理疗杂志,2000,23(6):353-355.
  • [13]Zhang Q,Chang Q,Cox RA,et al.Hyperbaric oxygen attenuates apoptosis and decreases inflammation in an ischemic wound mode.JInvest Dermatol,2008,128(8):2102-2112.
  • [14]Ratzenhofer-Komenda B,Offner A,Quehenberger F,et al.Hemodnamic and oxygenation profiles in the early period after hyperbar oxygen therapy:an observational study of intensive-care patients.Acta Anaesthesiol Scand,2003,47 (5):554-558.
  • [15]Korkmaz A,Oter S,Sadir S,et al.Exposure time related oxidative action of hyperbaric oxygen in rat brain.Neurochem Res,2008,33 (1):160-166.
  • [16]Carson S,McDonagh M,Russman B.Hyperbaric oxygen therapy for stroke:a systematic review of the evidence.Clin Rehabil,2005,9(8):8-9.
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