Objective To evaluate percutaneous coronary intervention(PCI) on coronary chronic total occlusion(CTO) lesions safety, clinical effectiveness, compared PCI and simple drug treatment of chronic coronary occlusion in patients with long - term prognosis. Methods From February 2008 to February 2010 Shangqiu City Department of Cardiology, First People' s Hospital, 82 cases of hospitalized patients, a total of 116 lesions after radial artery CTO intervention information. Test group: PCI group 50 cases of 67 lesions treated by interventional occlusion of blood vessels open. Drug treatment group :32 patients with 49 lesions due to surgery or surgery was not successful line of PCI given drug treatment alone. Analysis of the clinical symptoms of the two groups, the incidence of major complications; two groups of clinical follow - up 6 months follow - up cases were compared clinical end point event rate; review echocardiography and cardiac function and wall observed movement. Results 116 CTO lesions, 67 lesions after successful opening of the radial artery, 49 lesions could not open, the success rate of 57.8%. The two groups no significant difference in clinical characteristics. Forearm,3 cases of postoperative hematoma, no pulse disease 0, no other serious complications. Operation group with unstable angina, myocardial infarction and mortality were again lower than drug treatment group (P＜ 0. 05),echocardiography showed cardiac surgery group and wall motion was better than drug treatment group (P ＜0. 05). Conclusion The radial artery is safe and feasible intervention CTO lesions, a high success rate, no serious complications and chronic coronary occlusion may improve long - term prognosis of patients, improving quality of life and reduce mortality.