Influence of jinshuibao capsule on serum cystatin C and high sensitive C-reactive protein in chronic kidney disease patients

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Author:
MA Xi-chen(Department of Nephrology, the Affiliated Rizhao Hospital of Jining Medical College, Rizhao 276800, China)
TAN Yu-li()
GU hai-dong(Department of Nephrology, the Affiliated Rizhao Hospital of Jining Medical College, Rizhao 276800, China)
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
Volume 04, Issue 12, 2010
DOI:
10.3760/cma.j.issn 1673-8799.2010.12.16
Key Word:
Jinshuibao capsule;Chronic kidney disease;Cystatin C;CRP

Abstract: Objective To observe the influence of jinshuibao capsule on serum cystatin C and high sensitive C-reactive (hs-CRP)protein in chronic kidney disease patients (CKD). Methods Thirty-four cases CKD patients were randomly divided into two groups: control group (17 cases) and treatment group (treatment with jinshuibao capsules, 17 cases). Meanwhile, 17 healthy adults were taken as the normal control. The blood concentrations of cystatin C, hs-CRP, Scr and BUN were determined. Results The level of cystatin C, hs-CRP,Scr in all CKD patients were significantly higher than those in the normal control(P< 0. 05), the level of cystatin C, hs-CRP, Scr decreased after 8 weeks of conventional treatment (P > 0.05) , while those significantly decreased addition of jinshuibao capsule treatment(P <0. 05); Cystatin C and hs-CRP were positively correlated,but Cystatin C was negatively correlated with GFR. Conclusion The renal function and inflammation can be alleviated by jinshuibao capsule in early CKD patients, which could be slowed the progression of CKD.

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