Objective To investigate the characteristic of type 2 diabetes (T2DM)patients with coronary heart disease(CHD), and provide methods for prevention and treatment for patients who suffer from CHD.Methods The hospitalized patients from December 2006 to June 2010 were divided into three groups. The treatment group contents 46 examples who were T2DM with CHDM. The control group Ⅰ contents 30 examples who were T2DM without CHDM. The control group Ⅱ contents 50 examples who were CHD without T2DM. Compare their ordinary circumstances. The blood sugar, BP, TC, TG, HDL, LDL, HbA1C, C-P, Ins were measured. Insulin sensitive index(ISI)was calculated. Results Three groups have obvious statistical difference in BP, TC, LDL-C, ISI, HbA1C. Diabetic patients with coronary heart disease behave more common with three lesions. Conclusion In the clinical job should strengthen composite observation and treatment because the factors of atherosclerosis in T2DM patients are numerous and complex.