Objective To evaluate laparoscopic and open cholecystectomy for acute cholecystitis after the impact of gastrointestinal function and CRP. Methods 80 cases of acute cholecystitis and cholecystectomy were randomly divided into two groups. The laparoscopic group:40 underwent laparoscopic cholecystectomy.Laparotomy group:open cholecystectomy. Two groups of patients for evaluation of gastrointestinal function and CRP testing, were analyzed. Results Acute cholecystitis evaluation of gastrointestinal function. Laparoscopic group of 40 patients, Ⅰ grade 8 cases accounted for 20.0% , Ⅱ grade 15 cases accounted for 37.5% , Ⅲ grade 17 cases accounted for 42. 5%. Laparotomy group of 40 patients, Ⅰ 5 cases accounted for 12.5% , Ⅱ , 13 cases accounted for 32.5%, Ⅲ grade 22 cases accounted for 55.0%. Postoperative acute cholecystitis CRP test rating:laparoscopic group of 40 patients, normal in 6 cases accounted for 15.0% , slightly increased in 11 cases accounted for 27.5% , 40. 0% moderately elevated in 16 cases, severe increase of 7 cases 17.5%. Open group, 40 patients, normal in 2 cases(5.0%) , slightly increased in 13 cases (32. 5%), 35.0% moderately elevated in 14 cases, 11 cases of severe increased 27.5%. Conclusion The laparoscopic operation time was significantly lower than open surgery, avoiding the abdominal organs after abdominal exposure is conducive to rapid postoperative recovery of gastrointestinal function. Laparoscopy post-traumatic immune response than open surgery light.