Objective To evaluate the effect of endoscopic sclerosing agent injection for treatment of Peptic Ulcer Bleeding. Methods From July 2009 to July 2010,120 patients with haematemesis and/or hematochezia diagnosed as peptic ulcer by immediate endoscopy were randomly divided into two groups:endoscopic treated by the same endoscopist. Results The rate of hemostasis in therapy group was 96. 67% (58/60) , that in control group was 92.99% (P ＞ 0.05). The re-bleeding rates of the earler 3 h in the therapy group and control group were 1.72% (1/58) and 3.77% (2/53) , respectively, there was not significant differencein (P ＞0.05). The re-bleeding rates between 3 h and 24 h in the therapy group and control group were 3.45 % (2/58)and 16. 98% (9/53) ,respectively ,there was significant difference(P＜ 0.05). 2 months of follow up was made for the two groups, re-bleeding rates in the therapy group and control group were 1.72% (1/58) and 1.89% (1/53) ,respectively ,there was not significant difference(P ＞ 0.05). After 6 months of the observed, no one was found rebleeding. No complications related with treatment occurred in the two groups of patients. No significant differences are observed between the 2 groups in hospital stay, surgery and mortality. Conclusion Endoscopic treating peptic ulcer bleeding, and the effect of aethoxysklerol is better than epinephrine, they deserved for further application.