Clinical Study of Endoscopic Treatment in Patients with Peptic Ulcer Bleeding

( views:576, downloads:0 )
Author:
HOU Ya-li(Department of Gastroenterology, Yantai Yu huangding Hospital Afficialed to medical college of Qingdao University, Shandong 264000, China)
HUANG Liu-ye(Department of Gastroenterology, Yantai Yu huangding Hospital Afficialed to medical college of Qingdao University, Shandong 264000, China)
LIU Yun-xiang(Department of Gastroenterology, Yantai Yu huangding Hospital Afficialed to medical college of Qingdao University, Shandong 264000, China)
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
Volume 04, Issue 12, 2010
DOI:
10.3760/cma.j.issn 1673-8799.2010.12.04
Key Word:
Endoscopic therapy;Peptic ulcer bleeding;Sclerosing agent;Epinephrine

Abstract: Objective To evaluate the effect of endoscopic sclerosing agent injection for treatment of Peptic Ulcer Bleeding. Methods From July 2009 to July 2010,120 patients with haematemesis and/or hematochezia diagnosed as peptic ulcer by immediate endoscopy were randomly divided into two groups:endoscopic treated by the same endoscopist. Results The rate of hemostasis in therapy group was 96. 67% (58/60) , that in control group was 92.99% (P > 0.05). The re-bleeding rates of the earler 3 h in the therapy group and control group were 1.72% (1/58) and 3.77% (2/53) , respectively, there was not significant differencein (P >0.05). The re-bleeding rates between 3 h and 24 h in the therapy group and control group were 3.45 % (2/58)and 16. 98% (9/53) ,respectively ,there was significant difference(P< 0.05). 2 months of follow up was made for the two groups, re-bleeding rates in the therapy group and control group were 1.72% (1/58) and 1.89% (1/53) ,respectively ,there was not significant difference(P > 0.05). After 6 months of the observed, no one was found rebleeding. No complications related with treatment occurred in the two groups of patients. No significant differences are observed between the 2 groups in hospital stay, surgery and mortality. Conclusion Endoscopic treating peptic ulcer bleeding, and the effect of aethoxysklerol is better than epinephrine, they deserved for further application.

  • [1]聂玉强,李瑜元,吾惠生,等.消化性溃疡出血的FORREST分级及其与预后关系.内镜,1995,12:10-12.
  • [2]Thomopoulos KC,Mitropoulos JA,Katsakoulis EC,et al.Factors associated with failure of endoscopic injection haem ostasis in bleeding peptic ulcers.Sacand J Gastroen tero1,2001,36(6):664-668.
  • [3]Vallance P,Moncada S.Hyperdynamic circulation in cirrhosis:a role for nitric oxide.Lancet,1991,337:766.
  • [4]侯晓华,俞启纯,刘诗,等.高渗盐水局部注射治疗消化性溃疡出血的初步经验.中国内镜杂志,1996,13(2):303-304.
  • [5]唐洁婷,房静远.非静脉曲张性消化道出血的内镜治疗.临床内科杂志,2004,2l(5):294-296.
  • [6]Consensus conference:Therapeutic endoscopy and bleeding ulcers.JAMA,1989,262 (10):1369-1372.
  • [7]Lo CC,Hsu PI,Lo GH,et a.1 Comparison ofhemostatic efficacy for epi-nephrine injection alone and injection combined with hemoclip therapy in treating high-risk bleeding ulcers.Gastrointest Endosc,2006,63:767-773.
  • [8]Lin HJ,Perng CL,Lee Fy,et al.Endoscopic injection for the arrest of peptic ulcer hemorrhage:final results of a prospective,randomized comparative trial.Gastrointest Endosc,1993,39:15-19.
  • [9]Chung SCS,Leung JW,Sung JY,et al.Injection or heater probe for bleeding ulcer.Gastroenterology,1991,100:33-37.
  • [10]Cheng CL,Liu NJ,Lee CS,et al.Endoscopic management of Dieulafoylesionsinacutenonvaricealuppergastrointestinal bleeding.Dig Dis Sci,2004,49:1139-1144.
  • [11]张啸.消化内镜治疗.浙江大学出版社,2005:33.
  • [12]HuiAJ,Sung JJ.EndoscopicTreatmentofUpperGastrointestinal Bleed-ing.Curr Treat Options Gastroentero,2005,8:153-162.
  • [13]BUFFOLI F,GRAFFEO M,NICOSIA F.Peptic ulcer bleeding:comparison of two hemostatic procedures.Am J Gastroent erol,2001,96(1):89-94.
  • [14]Skok P,Krizman I,Skok M.Argon plasma coagulation versus injection sclerotherapy in peptic ulcer hemorrhage a prospective,controlled study.Hepatogastroenterology,2004,51:165-170.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn