You Position: Home > Paper

Oxaliplatin combined with fluorouracil, leucovorin treatment of advanced gastric cancer

( views:124, downloads:4 )
Author:
No author available
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
10
DOI:
10.3760/cma.j.issn1673-8799.2010.10.29
Key Word:
奥沙利铂;氟尿嘧啶;亚叶酸钙;晚期胃癌;化疗;Oxaliplatin;Fluorouracil;Leucovorin;Advanced gastric cancer;Chemotherapy

Abstract: Objective To observe oxaliplatin(L-OHP) combined with fluorouracil(Fu),leucovorin (CF) treatment of advanced gastric cancers and toxicity.Methods 60 patients with advanced gastric cancer patients given oxaliplatin 130 mg/m2,intravenous drip 2 h,day 1; leucovorin 200 mg/m2,intravenous infusion of 2 h,then quickly into the intravenous fluorouracil 400 mg/m2,fluorouracil 600 mg/m2 continuous infusion 44 h,repeated every 3 weeks.According to WHO criteria to evaluate the efficacy and toxicity.Results 60 patients were(CR) 6 patients of complete remission,partial remission(PR) in 14 patients,( SD) 30 cases of stability,(PD) 10 cases,efficiency 33%,clinical benefit rate of 83%,the average disease progression time of 5.2 months,average survival of 9.6 months and 1 year survival rate of 55%.The main side effects were nausea and vomiting,bone marrow suppression,and mild peripheral neuropathy.Conclusion L-OHP United FU,CF better treatment of advanced gastric cancer,toxicity can be tolerated,worthy of promotion.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn