Abstract： Objective To used the ethods in evidence-based care after severe brain injury observed in patients with salt wasting syndrome and care. Methods 46 patients with severe salt wasting syndrome after traumatic brain injury were randomly divided into evidence-based group and the conventional group, set up by the matron, care nurses, nurses evidence-based group, application of computer network retrieval literature, the real evidence ,reliability and usefulness of evaluation, the patients on the evidence-based practice evidence-based care, treatment and care measures for the two groups the same basis. Were observed in patients with disability and mortality,the results with the x2 test. Results Evidence-based group practice through evidence-based care,evidence-based group of disability, mortality was significantly lower than the conventional group (P ＜ 0. 05).Conclusion The implementation of evidence-based care for such patients not only improve the cure rate, but also improve the professional standards of nurses.