Abstract： Objective To explore the early reoxygenation and lying on the left side of neonatal HIE and follow-up study. Methods 123 cases of active movement in the 37 ～ 40 week pregnant women divided into two groups under the voluntary 63 cases ,60 cases of the control group. Observer Group in the conventional care,nutrition and psychological comfort, based on early to give pregnant women oxygen 2 L/min, 2 times/day, 30 mins/times, and in line with the left side lying, birth process oxygen and oxygen after birth, the newborn 30 minutes. Control group were given conventional measure of conventional care and mental psychological comfort, it was observed to deal with the situation of illness. Results Two groups of neonatal Apgar score 1 min, 5 min comparison, the difference was significant(P ＜ 0. 005, P ＜ 0. 01) ;two groups of neonatal after birth NBNA the score comparison, the difference was significant (P ＜ 0. 005 or P ＜ 0.05). 3,6,12,18,24,72,84,96 intelligent months from the development quotient (DQ) of comparison, significantly higher than those in the observation group (P ＜ 0. 01) ;the incidence of nervous system sequelae of comparison, the observation group were significantly lower in the control group (P ＜ 0. 05). Conclusion Early oxygen and left lying on the impact of neonatal HIE, can reduce the cerebral reperfusion injury and reduce side effects, improve the quality of life of children and the quality of the population.