Abstract： Objective To investigate the influences of Irbesartan on left ventricular hypertrophy and diastolic function in aged uygur patients with essential hypertension. Methods One hundred and thirty patients with 1-2stage essential hypertension were given Irbesartan 100 ～300 mg/d for twenty-four weeks. The change of blood pressure and heart beat before and after treatment was observed. The index of left ventricular end diastolic dimension ( LVDd), interventricular septal diameter ( IVSD ), left ventricular posterior wall diameter ( LVPWD )which reflecting the left ventricular hypertrophy were measured by M-mode ultrasound cardiography. Doppler echocardiographic recordings of flow velocity were obtained. Peak velocity in early diastole (E)and at atrial contraction(A) and mitral valve E-peak deceleration time were measured. E/A was calculated. Results After the treatment of Irbesartan for 12 weeks, blood pressure degraded,VA decreased significantly(P ＜ 0. 05 ),whereas VE and E/A increased significantly ( P ＜ 0. 05 ). LVID 、 IVST, LVPWT and LVMI decreased obviously ( P ＜0.05 ). Conclusion Irbesartan can obviously degrade the blood pressure and may significantly reverse left ventricular hypertrophy, improve the left ventricular diastolic function in super aged hypertensive patients.