Abstract： Objective To observe tripterygium wilfordii polypeptide (TWP)combined fosinopril treatment of children with nephrotic syndrome treatment of Henoch-Schonlein purpura nephritis. Methods from December 2006 to December 2009 in our hospital pediatric clinic, 38 patients were diagnosed as nephrotic syndrome in children with Henoch-Schonlein Purpura nephritis, respectively, were randomly divided into treatment group(20 cases of oral TWP joint Fosinopril)and control group, 18 patients( oral TWP) , observation of drugs on two groups of children with edema, hypertension, hematuria, proteinuria efficacy, using SPSS10. 0 software for statistical analysis. Results The complete remission in 18 cases ( 90% ), partial remission in 2 cases (10%). Control group, complete remission in 11 cases(61% ), partial remission in 6 cases(39% ), ineffective in 1 (6%)remission rate of the two groups, the difference was not significant( P ＞ 0. 05 ), but the treatment group edema subsided, blood pressure returned to normal, hematuria disappeared, urine protein was negative on average were significantly shorter than the control group, the difference was significant (P ＜ 0. 01 ).Conclusion The effect of TWP combined fosinopril treatment of children with nephrotic syndrome HenochSchonlein purpura nephritis is better than TWP alone and it is worth clinical application.