Evaluation of Asymptomatic Hypoglycemia in Type 2 Diabetics through Continuous Glucose Monitoring System

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Author:
WANG Yan(The Department of Endocrinology and Metabolism, The First People's Hospital of Yunnan Province, Kunming 650032, China)
GUAN Shou-ping(The Department of Endocrinology and Metabolism, The First People's Hospital of Yunnan Province, Kunming 650032, China)
KANG Ying(The Department of Endocrinology and Metabolism, The First People's Hospital of Yunnan Province, Kunming 650032, China)
()
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
Volume 04, Issue 06, 2010
DOI:
10.3760/cma.j.issn 1673-8799.2010.06.05
Key Word:
Continuous Glucose Monitoring System;Type 2 Diabetes Mellitus;Asymptomatic Hypoglycemia

Abstract: Objective Investigate character of asymptomatic hypoglycemia in patients of Type 2 diabetes mellitus. Methods For three days(65-72 hours) on end blood glycemia variations of 1147 Type 2 diabetics with stable glycemia control were monitored through Continuous Glucose Monitoring System(CGMS). Results ① Incidence of asymptomatic hypoglycemia was 25.54% in Type 2 diabetics, taking 60. 8% (697 patients ) of hypoglycemia cases. Incidence of asymptomatic hypoglycemia was negatively correlated on exponential curve with the course of diabetes( r = 0. 913, tr = 3. 636, P < 0. 05 ). ②Mean Blood Glucose (MBG) was negatively correlated with incidence of asymptomatic hypoglycemia on a hyperbolic curve or = -0. 963, P < 0. 01 ). ③With the maximal BG fluctuation (LAGE)being increasing, incidence of asymptomatic hypoglycemia increases. ④Asymptomatic hypoglycemia incidence was similar for men or women and was negatively correlated with age (for men:r = -0. 929, tr = 5. 613,P < 0. 01; for women: r = -0. 824, tr = 3.251, P < 0. 01 ). ⑤MBG of elderly subjects was higher than that of the none-elderly ( t = 6. 81, P < 0. 01 ) and incidence of hypoglycemia for the elderly was higher than that of the none-elderly(x2 = 60. 37 ,P < 0. 01 ). Conclusion ① Incidence of asymptomatic hypoglycemia of Type 2 diabetics is high and positively correlated with the course of diabetes. The lower MBG is maintained,the more LAGE is, the higher incidence of asymptomatic hypoglycemia is. ②Owered requirements for blood glucose control and heightened MBG for elderly diabetes patients can effectively reduce incidence of asymptomatic hypoglycemia. ③ Asymptomatic hypoglycemia can be detected timely and accurately through CGMS.

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